Statistical methods in relatedness and pedigree analysis
Dates: 10-14 January 2022. Please note that this course has been postponed until further notice.
Location: University of Oslo
Organiser: Magnus Dehli Vigeland
Credits: 4 ECTS.
Evaluation: The students will do a project after the course, delivering a written report within a month. The report will be marked as passed/not passed.
The course introduces statistical methods used in relatedness and pedigree analysis, with applications in forensic genetics, medical genetics and pedigree reconstruction.
The study of genetic relatedness and how genetic information flows in families, is central in a variety of important research fields, including medical genetics, forensics and animal breeding. The aim of this course is to introduce the students to the elegant concepts and results forming the theoretical foundation of genetic relatedness, and to present in some detail several modern applications. In the exercises we use R and the ped suite packages for pedigree analysis.
09-11 Introduction I: Pedigrees, genetics and probabilities
13-15 Introduction II: Pedigree analysis in R with the ped suite
09-11 Relatedness I: What does it mean to be related? IBD and coefficients of relatedness
13-15 Relatedness II: Why are some siblings more equal than others? Distributions of realised relatedness
09-11 Forensic applications I
13-15 Inference of relatedness and pedigree reconstruction
09-11 Forensic applications II
13-15 Segregation analysis in medical genetics
09-11 Genealogical triangulation
13-16:30 Case study and wrap up
Learning outcomes and competence
After completing the course the student will have knowledge about:
- classical concepts and methods of statistical genetics
- important applications of pedigrees and relatedness in forensic and medical genetics
- software for visualising and analysing pedigrees and marker data
Basic knowledge of genetics and probability. Some experience with R is an advantage but not required.