In order to have enough power, genetic studies need to be carried out at very large scales and usually require sample sizes larger than 10,000s. This poses biostatistic- and bioinformatic challenges at different levels. ‘Large genetic studies in biobanks: from registries screening, to interpretation of GWAS and beyond‘ will cover challenges facing the use of biobanks and registries for large scale genetic analyses; from the design of the studies, to the execution, the analyses of the data (beyond single p-value analyses), and the functional interpretation of the results.